Out goes Udinese star, Emmanuel Agyemang Baduand in comes Celtic workaholic, Mubarak Wakaso who will partner Parma tough tackler, Afriyie Acquah in central midfield as the Black Stars chase qualification to the quarter finals.
Goalkeeper Razak Brimah and the defensive pairing of Harrison Afful, Baba Abdul Rahman, Jonathan Mensah and Daniel Amartey all retain their starting spots.
Andre Ayew and Christian Atsu complement Wakaso and Acquah in midfield whilst captain Asamoah Gyan and Jordan Ayew lead the attack against Bafana Bafana.
The Black Stars must win to confirm Ghana’s spot in the last 8 against a South Africa side still chasing a first win in the tournament that could even not be enough.
Algeria take on group leaders, Senegal in the other group match which will be played concurrently with only teh top two assured of progress to the next round.
Kickofff is at 18:00 hrs GMT.
Ghana line up versus South Africa:
Razak Brimah, Harrison Afful, Baba Abdul Rahman, Jonathan Mensah, Daniel Amartey, Afriyie Acquah, Mubarak Wakaso, Christian Atsu, Andre Ayew, Asamoah Gyan, Jordan Ayew