Defending champions of the MTN FA Cup, Asante Kotoko had no problems in the round of 64 dispatching BYFA 2-0.
The Porcupine Warriors did endure a tough first half and had to wait till the 51st minute before breaking the deadlock through a Fabio Gama penalty.
Nine minutes later, Mariano Barreto’s men doubled their lead through a curler by Emmanuel Keyekeh.
Kotoko held on to start their title defence on a strong note as they march on to the round of 32 stage after a comfortable victory at the Nana Gyamfi Park in Bekwai.
Hearts of Oak came into the Liberty game with a strong lineup as the club seeks to win the double this season.
The Phobians started the match stronger taking the lead through Daniel Afriyie Barnieh.
Kwadwo Obeng Jnr doubled Hearts’ lead on the stroke of halftime to score in his third consecutive game.
A delicate chip by Barnieh sent Samuel Boadu’s men three up as they picked up a comfortable victory.
Out of form Medeama returned to winning ways through a solitary goal from Zakaria Mumuni in the first half against Eleven Wise.
AshantiGold beat fellow Premier League side King Faisal by a sole goal scored by Gordon K Brokelyn at the Ohene Ameyaw park.
WAFA dismantled Akatsi All Stars 4-0 with goals coming from Sampson Agyapong, Marvin Owusu, Basit Issah and Emmanuel Agyemang.
Phar Rangers pulled one of the upsets of the competition so far beating Dreams FC 4-2 on penalties after the game ended 2-2 in regular time.
A Benjamin Boateng second half brace was enough to send Elmina Sharks past Metro Stars to the next round.
Division One side Tema Youth thrashed Inter Allies beating the Premier League side 5-1.
Sky FC also brushed aside Premier League side Ebusua Dwarfs, winning 2-0.
Aduana Stars beat Eleven Wonders courtesy a goal from Isaac Kwain.
Berekum Chelsea were victorious against Bofoakwa Tano FC, beating them 2-1.
In earlier results, Great Olympics beat Charity Stars FC 2-0.
Karela United beat Sekondi Hasacaas 4-2 on penalties after the game ended 1-1 in regular time.
All teams who have progressed to the round of 32 stage earn GH ₵4,000 each.
MTN FA Cup round of 64 results:
BYFA 0-2 Asante Kotoko
Hearts of Oak 3-0 Liberty Professionals
King Faisal 0-1 AshantiGold
WAFA SC 4-0 Akatsi All Stars
Phar Rangers 2-2 Dreams Fc (4-2 pens)
Tema Youth 5-1 Inter Allies
Elmina Sharks 2-0 Metro Stars
Sky FC 2-0 Ebusua Dwarfs
Aduana Stars 1-0 Eleven Wonders
Berekum Chelsea 2-1 Bofoakwa Tano FC
Eleven Wise 0-1 Medeama SC
Great Olympics 2-0 Charity Stars FC
Sekondi Hasacaas 1-1 Karela United (2-4 pens)